Key result
Combination therapy with warfarin and aspirin did not significantly increase hemorrhage rates compared to warfarin alone in patients with atrial fibrillation (7.0 vs 5.2 per 100 person-years; P=0.29).
Why the study?
Does warfarin and aspirin combination therapy increase hemorrhagic outcomes compared to warfarin alone in patients with atrial fibrillation?
Population
695 patients ≥45 years old with atrial fibrillation as the indication for anticoagulation, without…
Comparison
Warfarin and aspirin combination therapy vs Warfarin alone
Design
Cohort
Authors
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Does not support adding aspirin to warfarin in AF; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=695)
No
Does warfarin and aspirin combination therapy increase hemorrhagic outcomes compared to warfarin alone in patients with atrial fibrillation?
Absolute Event Rate: 7% vs 5.2%
p-value: p=0.29
In a retrospective cohort of AF patients, adding aspirin to warfarin did not significantly increase overall or major hemorrhage rates compared to warfarin alone, though bleeds occurred at lower INR levels.
Curiale et al. (2011) conducted a cohort in Atrial fibrillation (n=695). Warfarin and aspirin vs. Warfarin alone was evaluated on Hemorrhage rates (p=0.29). Combination therapy with warfarin and aspirin did not significantly increase hemorrhage rates compared to warfarin alone in patients with atrial fibrillation (7.0 vs 5.2 per 100 person-years; P=0.29).
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