Key result
Combination therapy with warfarin and aspirin in atrial fibrillation is associated with increased bleeding compared to warfarin alone.
Why the study?
Does warfarin and aspirin combination therapy increase hemorrhagic outcomes compared to warfarin alone in patients with atrial fibrillation?
Does warfarin and aspirin combination therapy increase hemorrhagic outcomes compared to warfarin alone in patients with atrial fibrillation?
May support avoiding combination therapy in AF; leaves open confirmation by randomized trials.
Anticoagulation with warfarin is an important therapy for preventing strokes in patients with atrial fibrillation (AF). Physicians often combine warfarin with aspirin despite evidence for increased bleeding. We investigated the hemorrhagic outcomes related to the differential management of AF with warfarin alone versus combination therapy.
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Curiale et al. (2011) studied this question. Combination therapy with warfarin and aspirin in atrial fibrillation is associated with increased bleeding compared to warfarin alone.
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