September 1, 2003Journal of Cardiovascular Electrophysiology
Prevention of Vascular Events in Patients with Atrial Fibrillation:
Why the study?
Does oral anticoagulation or aspirin prevent vascular events in patients with atrial fibrillation?
Population
Patients with atrial fibrillation (AF)
Comparison
Oral anticoagulation (such as warfarin) or aspirin vs Placebo or active comparator (warfarin vs aspirin)
Design
Review
Authors
Discussion
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Implication
Supports anticoagulation preference in AF despite bleeding risk; leaves open optimal agent selection in contemporary cohorts.
Structured PICO
Does oral anticoagulation or aspirin prevent vascular events in patients with atrial fibrillation?
P
Population
Patients with atrial fibrillation (AF)
I
Intervention
Oral anticoagulation (such as warfarin) or aspirin
C
Comparator
Placebo or active comparator (warfarin vs aspirin)
O
Outcome
Vascular events, particularly strokehard clinical
Oral anticoagulation is highly effective for stroke prevention in atrial fibrillation, offering superior efficacy to aspirin but with an increased risk of major bleeding.
Cite This Study
Stuart J. Connolly (2003) studied this question.