What question did this study set out to answer?

This research aims to evaluate the association of race, ethnicity, and donor type with overall survival in patients receiving PTCy for HCT.

December 8, 2025Blood

Overall survival after post-transplant cyclophosphamide (PTCy) peripheral blood hematopoietic cell transplantation (HCT) differs by race, ethnicity, and donor

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Secondary analysis reveals race and donor type impact overall survival in hematopoietic cell transplantation, suggesting disparities exist.

This research aims to evaluate the association of race, ethnicity, and donor type with overall survival in patients receiving PTCy for HCT.
Conducted a secondary analysis using a dataset from the Center for International Blood and Marrow Transplantation Research Program.
Included adult patients (over 19 years) who underwent peripheral blood allogeneic HCT from 2013-2018.
Assessed overall survival using Kaplan-Meier curves and Cox Proportional Hazards models.
Of 4,031 patients, Hispanic and NHB patients had lower overall survival compared to NHW patients.
Higher OS observed in younger patients and those with non-malignant diseases compared to myelodysplastic disorders.
MUD patients receiving PTCy had the highest OS (65%) compared to other donor types.

Herr et al. (2025) studied this question.

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Secondary analysis reveals race and donor type impact overall survival in hematopoietic cell transplantation, suggesting disparities exist.