What question did this study set out to answer?

This analysis aims to evaluate the effectiveness of the FLAG-Ida-Ven regimen in treating acute myeloid leukemia (AML) in real-world settings.

December 8, 2025Blood

High remission rates with FLAG-ida-venetoclax in acute myeloid leukemia: “Less is More” on days of venetoclax in the intensive regimen

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This analysis aims to evaluate the effectiveness of the FLAG-Ida-Ven regimen in treating acute myeloid leukemia (AML) in real-world settings.
Reviewed medical records of 32 adults with AML treated with FLAG-Ida-Ven in both frontline and relapsed settings.
Assessed overall survival and event-free survival using Kaplan-Meier method.
Categorized patients based on treatment setting, age, and risk factors.
Overall response rates were 90% in frontline, 86% in second induction, and 67% in relapsed cohorts.
Significant neutropenia and thrombocytopenia occurred, with high incidence of febrile neutropenia across cohorts.
Noted trends in response rates and mortality among different treatment durations of venetoclax.

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Implication

Clinical trials show FLAG-Ida-Ven improves response rates in frontline acute myeloid leukemia treatment, highlighting risks like neutropenia and hemorrhage.

Cite This Study

Fedorov et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3b8 https://doi.org/10.1182/blood-2025-1666

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Implication

Clinical trials show FLAG-Ida-Ven improves response rates in frontline acute myeloid leukemia treatment, highlighting risks like neutropenia and hemorrhage.

High remission rates with FLAG-ida-venetoclax in acute myeloid leukemia: “Less is More” on days of venetoclax in the intensive regimen

Key Points

Discussion

Implication

Cite This Study

High remission rates with FLAG-ida-venetoclax in acute myeloid leukemia: “Less is More” on days of venetoclax in the intensive regimen

Key Points

Discussion

Implication

Cite This Study

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