What question did this study set out to answer?

This analysis aims to compare the effects of venetoclax addition to different chemotherapy regimens in relapsed or refractory acute myeloid leukemia.

December 8, 2025BloodOpen Access

The addition of venetoclax to FLAG IDA or FCE in relapsed or refractory (R/R) acute myeloid leukemia (AML)

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This analysis aims to compare the effects of venetoclax addition to different chemotherapy regimens in relapsed or refractory acute myeloid leukemia.
Conducted a retrospective analysis of adult R/R AML patients at City of Hope between 2017 and 2023.
Compared FLAG-IDA and FCE treatments with and without venetoclax in patients.
Evaluated complete response rates and overall survival rates from the start of treatment.
Of 116 eligible patients, the overall complete response rates were similar for both chemotherapy regimens.
Febrile neutropenia occurred in 89% of patients, with no difference between treatment groups.
Patients receiving venetoclax showed a trend toward more complete responses but without statistical significance.

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Implication

Retrospective analysis demonstrates comparable complete response rates in R/R AML with venetoclax addition, suggesting potential benefits for febrile neutropenia.

Cite This Study

Ngo et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3c6 https://doi.org/10.1182/blood-2025-1684

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Implication

Retrospective analysis demonstrates comparable complete response rates in R/R AML with venetoclax addition, suggesting potential benefits for febrile neutropenia.

The addition of venetoclax to FLAG IDA or FCE in relapsed or refractory (R/R) acute myeloid leukemia (AML)

Key Points

Discussion

Implication

Cite This Study

The addition of venetoclax to FLAG IDA or FCE in relapsed or refractory (R/R) acute myeloid leukemia (AML)

Key Points

Discussion

Implication

Cite This Study

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