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December 8, 2025BloodOpen Access

Comorbid but transplantable: Favorable outcomes with RIC and ptcy in patients with an HCT-CI score of 3 or higher in the modern era

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Authors

JRJulia Ribes‐AmorósLHLidia HurtadoAMAlberto Mussetti

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Overview

Retrospective analysis shows improved overall survival and non-relapse mortality in patients with HCT-CI >3, suggesting RIC and PTCy enhance transplant eligibility.

Key Points

  • This study aims to evaluate the outcomes of patients with an HCT-CI score greater than 3 undergoing hematopoietic cell transplantation.
  • Monocentric retrospective study at Institut Català d'Oncologia
  • Included adults with oncohematological diseases and HCT-CI >3
  • Primary endpoint was non-relapse mortality, secondary endpoints included overall survival and progression-free survival
  • At +24 months, non-relapse mortality was 22%, overall survival was 58%, and progression-free survival was 55%
  • Acute graft-versus-host-disease occurred in 48% of patients
  • An HCT-CI of >4 was linked to decreased overall survival and progression-free survival

Cite This Study

Ribes‐Amorós et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3e7https://doi.org/10.1182/blood-2025-2430
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Also Consider

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  4. 4Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT2005 · 2,979 citations
  5. 5Refined elderly comorbidity index is highly predictive of post-transplant survival in older adults with Acute Myeloid Leukemia and myelodysplastic syndrome2025