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December 8, 2025BloodOpen Access

Refined elderly comorbidity index is highly predictive of post-transplant survival in older adults with Acute Myeloid Leukemia and myelodysplastic syndrome

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Authors

FAFnu AmishaRRReshma RamlalRFRawan Faramand

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Overview

Single-center study demonstrates prognostic significance of refined elderly comorbidity index in older adults undergoing hematopoietic cell transplantation for AML/MDS.

Key Points

  • This research aims to evaluate the prognostic significance of the refined elderly comorbidity index (RECI) for predicting non-relapse mortality and overall survival in older adults undergoing transplantation for acute myeloid leukemia and myelodysplastic syndrome.
  • Single-center retrospective study of patients aged ≥60 years undergoing hematopoietic cell transplantation for AML/MDS from 2005 to 2023.
  • Patients were risk stratified using the European LeukemiaNet and the Revised International Prognostic Scoring System.
  • Multivariate Cox model analyzed predictors of non-relapse mortality and overall survival, developing the RECI based on significant hazard ratios.
  • 941 older adults were included; 22% experienced non-relapse mortality and 59% overall survival at 2 years post-transplant.
  • RECI was established for risk stratification, identifying three groups with different 2-year non-relapse mortality rates (15%, 22%, and 38%).
  • Prognostic significance of RECI was validated, correlating scores with overall survival rates of 66%, 58%, and 44% for respective risk categories.

Cite This Study

Amisha et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e42dhttps://doi.org/10.1182/blood-2025-6076
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comorbid but transplantable: Favorable outcomes with RIC and ptcy in patients with an HCT-CI score of 3 or higher in the modern era2025
  2. 2Frailty-comorbidity discordance and non-relapse mortality after allogeneic hematopoietic cell transplantation.2026
  3. 3Total marrow irradiation-based, intensified reduced-intensity conditioning regimen for hematopoietic cell transplantation in patients aged 60 years or older: A prospective study2025
  4. 4Influence of comorbidities on outcome in 1102 patients with an allogeneic hematopoietic stem cell transplantation2024 · 3 citations
  5. 5Frailty as a prognostic factor in younger adult patients with Acute Myeloid Leukemia undergoing allogeneic stem cell transplantation2025