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December 8, 2025BloodOpen Access

Impact of extranodal involvement in stage I aggressive B-cell lymphoma in the rituximab era: An individual patient data meta-analysis of two Phase III dshnhl/GLA trials

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Authors

KCKonstantinos ChristofyllakisMBMoritz BewarderLTLorenz Truemper

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Overview

Meta-analysis shows extranodal stage I large B-cell lymphoma does not worsen survival outcomes, suggesting targeted radiotherapy may be unnecessary.

Key Points

  • This analysis aims to assess the prognostic impact of extranodal involvement in patients with stage I aggressive B-cell lymphoma in the context of rituximab treatment.
  • Conducted individual patient data meta-analysis of two Phase III trials (FLYER, UNFOLDER)
  • Included patients aged under 61 with stage I LBCL treated with R-CHOP
  • Evaluated overall survival and progression-free survival using Kaplan-Meier and Cox regression analyses
  • Out of 1283 patients, 505 had stage I disease; 137 had extranodal involvement
  • Extranodal disease did not associate with inferior overall survival or progression-free survival
  • Elevated LDH was identified as an independent predictor of worse overall survival in stage I patients

Cite This Study

Christofyllakis et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4c0https://doi.org/10.1182/blood-2025-469
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Also Consider

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  4. 4A multicenter, single-arm study of camrelizumab combined with rituximab followed by R-CHOP as first-line treatment for young patients with primary extranodal diffuse large B-cell lymphoma: The credit trial2025
  5. 5Definitive radiotherapy for early-stage follicular lymphoma: A retrospective study over two decades at a single institution2026