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December 8, 2025BloodOpen Access

Household material hardship as a barrier to accessing sickle cell disease curative therapy

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Authors

PMPaul MorganChildren's Hospital of PittsburghLDLeanne DuhaneyBoston Children's HospitalCFCaroline FryMassachusetts Institute of Technology

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Overview

Cross-sectional study identifies household material hardship as a barrier to gene therapy access for sickle cell disease.

Key Points

  • To assess the impact of household material hardship on access to gene therapy for children with sickle cell disease.
  • Cross-sectional study conducted at Boston Children's Hospital
  • Involved children aged 2 to <18 years with sickle cell disease
  • Surveys assessed modifiable social risk factors and ability to pursue curative therapy
  • Logistic regression analyzed the relationship between material hardship and therapy access
  • Descriptive statistics summarized cohort demographics.
  • 40% of parents reported ability to obtain curative therapy for their child
  • 54% of children lived in low-income households
  • 60% experienced at least one form of household material hardship
  • HMH independently associated with 95% lower odds of obtaining therapy
  • Each additional hardship domain decreased therapy access odds by 35%.

Cite This Study

Morgan et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e551https://doi.org/10.1182/blood-2025-2672
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Out of Reach: Understanding Resource Barriers to Gene Therapy for Pediatric Patients With Sickle Cell Disease2026
  2. 2The feasibility of collecting social determinants of health in the national multi-center GRASP sickle cell gene therapy trial2025
  3. 3I know that one day I will be cured, and all will be well: Perspectives on acceptability of curative therapies for sickle cell disease in Tanzania.2025 · 1 citations
  4. 4“I Know that One Day I Will Be Cured”: Perspectives on Acceptability of Curative Therapies for Sickle Cell Disease in Tanzania2026
  5. 5The Journey of Gene Therapy in Sickle Cell Disease: How Molecular Advances Meet Clinical Care2026