December 8, 2025Blood
The feasibility of collecting social determinants of health in the national multi-center GRASP sickle cell gene therapy trial
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Overview
Clinical trial assesses the feasibility of collecting social determinants of health data in sickle cell gene therapy, highlighting poverty's impact on outcomes.
Key Points
- To evaluate the feasibility of collecting poverty-related data in a multi-center gene therapy trial for sickle cell disease.
- Phase II, single-arm trial involving patients aged 13-40 with clinically severe sickle cell disease.
- Patients completed a 21-item Household Survey at baseline and 24-month follow-up.
- Data collection monitored centrally, with surveys available in multiple languages.
- Primary exposure of interest was household material hardship, including food and housing insecurity.
- 100% of participants completed the baseline Household Survey across 8 sites.
- All surveys had evaluable household material hardship data.
- 38% of participants reported exposure to household material hardships, mainly food and housing insecurity.
Cite This Study
London et al. (2025) studied this question.