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December 8, 2025Blood

Identification of biomarkers to predict disease progression via molecular analysis of patients (pts) with low-risk myelofibrosis (MF) enrolled in the MOST study

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Authors

EREllen K. RitchieECErin L. CrowgeyEBEvan Braunstein

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Overview

Observational analysis identifies biomarkers, including JAK2V617F variant allele frequency, for predicting disease progression in myelofibrosis.

Key Points

  • This analysis aimed to identify biomarkers predicting disease progression in patients with low-risk myelofibrosis.
  • Analyzed data from the Myelofibrosis and Essential Thrombocythemia Observational Study (MOST)
  • Utilized RNA sequencing and gene expression analysis for correlation with disease progression
  • Identified and compared gene expression patterns in patients with and without progression
  • Identified JAK2V617F variant allele frequency as predictive of disease progression
  • Differential gene expression found 560 downregulated and 1524 upregulated genes in the MY cohort
  • Pathway enrichment analysis highlighted key pathways including tumor microenvironment and cell cycle checkpoints

Cite This Study

Ritchie et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e592https://doi.org/10.1182/blood-2025-5526
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations2024 · 11 citations
  2. 2Predictors of fibrotic progression in myeloproliferative neoplasms: A real-world retrospective cohort study.2026
  3. 3Transcriptomic analysis of CD34⁺ cells in myelofibrosis highlights their role in extracellular matrix dysregulation and marrow fibrosis2025 · 1 citations
  4. 4Data from Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations2024
  5. 5Proteomic analysis identifying biomarkers in the progression from essential thrombocythemia to post-essential thrombocythemia myelofibrosis: A retrospective cohort study2025