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December 8, 2025BloodOpen Access

Characterisation of the megakaryocyte proteome in patients with Philadelphia negative myeloproliferative neoplasms

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Authors

CBCavan BennettLDLaura F. Dagley

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Overview

Mass spectrometry identifies distinct megakaryocyte proteomes in primary myelofibrosis and polycythemia vera, suggesting potential biomarkers for diagnosis.

Key Points

  • To characterize the megakaryocyte proteome in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs).
  • Conducted mass spectrometry-based proteomic analysis of in-vivo megakaryocytes from bone marrow samples.
  • Utilized deep visual proteomics and laser-capture micro-dissection to isolate megakaryocytes.
  • Performed pathway enrichment analysis using Reactome software.
  • Identified 4875 proteins, with significant differences among megakaryocytes from PMF, PV, and ET.
  • Revealed disease-specific proteomic signatures and differentially expressed proteins among MPN subgroups.
  • Highlighted potential biomarkers and pathways related to innate immunity in PMF and ET.

Cite This Study

Bennett et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5a0https://doi.org/10.1182/blood-2025-5539
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  1. 1Multi-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis2024 · 1 citations
  2. 2A Proteomics-Driven Machine Learning Tool for Distinguishing ET from pre-PMF2025
  3. 3Proteomic analysis identifying biomarkers in the progression from essential thrombocythemia to post-essential thrombocythemia myelofibrosis: A retrospective cohort study2025
  4. 4Single cell transcriptional profiling reveals distinct subsets of human megakaryocytes in myelofibrosis2025
  5. 5Peripheral blood plasma proteomics reveals dysregulated cholesterol transport and complement pathways in myeloproliferative neoplasms2025