Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

The anti-MPL antibody AMM2 prevents cardiovascular dysfunction in a mouse model of myeloproliferative neoplasms

View Full Paper
Ask AI
Bookmark
Share

Authors

HZHaoyi Zheng

Discussion

Loading...

Member takes

Overview

An intervention using AMM2 maintains cardiac function in MPN mice with thrombosis, suggesting a novel therapeutic strategy.

Key Points

  • The research aimed to determine if the monoclonal antibody AMM2 could prevent cardiovascular dysfunction in a mouse model of myeloproliferative neoplasms.
  • Mice with JAK2V617F-mutant blood cells and wild-type endothelial cells were created via bone marrow transplantation.
  • Mice were fed regular or high-fat diets, with AMM2 treatment administered intravenously every 10 days for 40 days in some.
  • Cardiac function was assessed using echocardiography, and single-cell RNA sequencing was performed for molecular analysis.
  • AMM2 treatment preserved left ventricular ejection fraction and cardiac function in JAK2V617F-mutant mice on a high-fat diet.
  • Histological analysis revealed that AMM2 reversed endocardial disruption and fibrosis caused by high-fat diet.
  • Gene set enrichment analysis showed that high-fat diet altered signaling pathways related to inflammation and endothelial-to-mesenchymal transition, which AMM2 mitigated.

Cite This Study

Haoyi Zheng (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5afhttps://doi.org/10.1182/blood-2025-5544
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding Endothelial MPL and JAK2V617F Mutation: Insight Into Cardiovascular Dysfunction in Myeloproliferative Neoplasms2024 · 13 citations
  2. 2Interleukin-12 and TNFα signaling drives parallel evolution of independent leukemic clones in JAK2V617F mutant myeloproliferative neoplasms2025
  3. 3Single-cell transcriptomic studies reveal altered heterogeneity in CD41 enriched megakaryocytes after targeted therapy in myeloproliferative neoplasm2025
  4. 4PITPβ loss disrupts malignant pAKT activation to ameliorate Jak2 V617F-induced myeloproliferative neoplasms (MPN) in mice2025 · 1 citations
  5. 5HiJAKing the Hematopoietic System: A Low-Frequency JAK2V617F Clone Drives Myeloproliferative Neoplasm Pathology2025 · 3 citations