What question did this study set out to answer?

The aim is to characterize the incidence of second primary malignancies following bispecific antibody therapy for lymphoid malignancies.

December 8, 2025Blood

Incidence of second primary malignancies (SPMs) following bispecific antibody (BsAb) therapy for lymphoid malignancies: A descriptive analysis of clinical trials

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Authors

THTalal HilalCancer Clinic

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Implication

Descriptive analysis evaluates cumulative incidence of second primary malignancies in patients treated with bispecific antibodies for lymphoid malignancies, indicating low rates compared to CAR-T cell

Key Points

The aim is to characterize the incidence of second primary malignancies following bispecific antibody therapy for lymphoid malignancies.
Systematic literature search for clinical trials of FDA-approved bispecific antibodies for hematological malignancies.
Review of trial reports for documentation of second primary malignancies in patients receiving bispecific antibodies.
Pooled analysis of trials focusing on long-term safety data and incidence rates of SPMs.
19 clinical trials identified with 5,133 patients across ALL, MM, and NHL.
Crude incidence of 0.16% and cumulative incidence rate of 0.08 per 100-person years for SPMs.
Most trials (84%) evaluated BsAbs as monotherapy, with median follow-up of 14.3 months.

Cite This Study

Talal Hilal (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5d7 https://doi.org/10.1182/blood-2025-8071

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Incidence of second primary malignancies (SPMs) following bispecific antibody (BsAb) therapy for lymphoid malignancies: A descriptive analysis of clinical trials

Discussion

Member takes

Implication

Key Points

Cite This Study

Incidence of second primary malignancies (SPMs) following bispecific antibody (BsAb) therapy for lymphoid malignancies: A descriptive analysis of clinical trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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