What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

This meta-analysis aims to analyze the incidence of hematotoxicity and immune deficits associated with bispecific antibodies in patients with lymphoma and multiple myeloma.

December 8, 2025BloodOpen Access

Hematotoxicity and immune deficits with bispecific antibodies: A systematic review and meta-analysis in lymphoma and multiple myeloma

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Authors

TTTobias TixLMU Klinikum ECEdward R. Scheffer CliffBrigham and Women's Hospital DHDoris K. HansenMoffitt Cancer Center

Discussion

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Implication

Systematic review and meta-analysis reveals high rates of hematotoxicity and immune deficits in lymphoma and multiple myeloma patients treated with bispecific antibodies, indicating a need for careful

Key Points

This meta-analysis aims to analyze the incidence of hematotoxicity and immune deficits associated with bispecific antibodies in patients with lymphoma and multiple myeloma.
Systematic review and meta-analysis of studies involving adult patients with lymphoma or multiple myeloma treated with bispecific antibodies.
Included 33 studies with a total of 3,557 patients, focusing on FDA-approved and investigational treatments.
Analyses of cytopenia incidence and hematologic toxicities were conducted using random effects models.
Pooled incidence rates showed anemia at 38.7%, higher in multiple myeloma than lymphoma (49.2% vs. 30.7%).
Neutropenia occurred in 41.3% of patients overall, with higher rates in multiple myeloma (51.8%).
Lymphopenia affected 24.9% of patients, notably more prevalent in those with multiple myeloma (32.9%).

Cite This Study

Tix et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1d0 https://doi.org/10.1182/blood-2025-8135

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Hematotoxicity and immune deficits with bispecific antibodies: A systematic review and meta-analysis in lymphoma and multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

Hematotoxicity and immune deficits with bispecific antibodies: A systematic review and meta-analysis in lymphoma and multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

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