LAX1 as a core biomarker in Alzheimer’s disease and periodontitis via the STAT signaling pathway

Han Guo; Tianyuan Guo; Xue Wang; Yang Bao; Zhiyong Zhang; Fang Xue; Dongmei Cheng

doi:10.1186/s12877-025-06865-x

December 12, 2025BMC GeriatricsOpen Access

LAX1 as a core biomarker in Alzheimer’s disease and periodontitis via the STAT signaling pathway

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Key Points

This research investigates the role of LAX1 as a biomarker and therapeutic target in Alzheimer’s disease and periodontitis.
Analyzed the functions of LAX1 in the context of STAT signaling pathway
Examined its impact on neuroinflammation and periodontal destruction
Identified its potential as a blood-based biomarker
LAX1 is involved in STAT-dependent neuroinflammation
LAX1 serves as a biomarker for both Alzheimer’s disease and periodontitis
Research suggests LAX1 is a promising druggable checkpoint for treatment strategies.

Implication

Research reveals LAX1 as a biomarker for neuroinflammation in Alzheimer’s disease and periodontitis, suggesting potential treatment targets.

Abstract

LAX1 gates STAT-dependent neuroinflammation and periodontal destruction, offering a druggable checkpoint and blood-based biomarker for these convergent chronic diseases.

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Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/6940190c2d562116f28f62fa https://doi.org/10.1186/s12877-025-06865-x

View Full Paper

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LAX1 as a core biomarker in Alzheimer’s disease and periodontitis via the STAT signaling pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

LAX1 as a core biomarker in Alzheimer’s disease and periodontitis via the STAT signaling pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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