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December 11, 2025Parasites & VectorsOpen Access

Diagnostic performance of a Strongyloides IgG4 Rapid Test in detecting human Strongyloides stercoralis infection

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Authors

RCRubén O. CiminoNational University of SaltaESErnesto Candela SentiUniversitat de ValènciaTGT.E. GarcíaUniversitario Francisco de Asís

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Implication

Cross-sectional study evaluates diagnostic performance of SsRapid, showing higher seroprevalence and sensitivity in Strongyloides stercoralis detection.

Key Points

  • The study aims to evaluate the diagnostic performance of the SsRapid test for detecting Strongyloides stercoralis.
  • Cross-sectional study in indigenous communities of Puerto Iguazú, Argentina, in 2023.
  • Stool and serum samples collected and analyzed for S. stercoralis detection using coprological methods and ELISA tests.
  • Diagnostic performance assessed with conventional analysis and latent class analysis to estimate sensitivity and specificity.
  • Copro-parasitological prevalence of STHs was 69.7%, with S. stercoralis's prevalence at 25.7%.
  • Seroprevalence of S. stercoralis was 51.3% with SsRapid and 39.4% with NIE-ELISA, showing a significant difference (P = 0.0049).
  • Sensitivity of SsRapid was 86.8% compared to coprological methods, and LAC estimated true sensitivity of SsRapid at 94.3% and specificity of 95.9%.

Cite This Study

Cimino et al. (2025) studied this question.

synapsesocial.com/papers/694019342d562116f28f6e6dhttps://doi.org/10.1186/s13071-025-07154-7
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