What question did this study set out to answer?

This research aims to determine the processing of proopiomelanocortin and its effects on keratinocytes.

December 11, 2025Scientific ReportsOpen Access

Extracellular processing of proopiomelanocortin generates short beta endorphin that regulates rat keratinocytes via the delta opioid receptor

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Authors

HYHiroyuki YamamotoShizuoka University YSYoshikazu SawaguchiToin University of Yokohama AKAyaka KoidaAichi Shukutoku University

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Implication

Investigations show beta endorphin from proopiomelanocortin enhances skin barrier function in rat keratinocytes, suggesting therapeutic potential for atopic dermatitis.

Key Points

This research aims to determine the processing of proopiomelanocortin and its effects on keratinocytes.
Analyzed skin extracts from atopic dermatitis lesions using immunoprecipitation and MALDI-TOF MS.
Examined opioid receptor expression in fetal rat skin keratinocytes through RT-PCR.
Conducted functional assays to evaluate the effects of beta endorphin on cAMP levels.
Identified beta endorphin(1-9) as a major derivative from proopiomelanocortin in skin lesions.
Beta endorphin reduced cAMP levels via delta opioid receptor signaling.
Differential gene expression analysis revealed modulation of collagen and hyaluronic acid-related genes.

Cite This Study

Yamamoto et al. (2025) studied this question.

synapsesocial.com/papers/69401b0d2d562116f28f70b5 https://doi.org/10.1038/s41598-025-31279-5

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Implication

Investigations show beta endorphin from proopiomelanocortin enhances skin barrier function in rat keratinocytes, suggesting therapeutic potential for atopic dermatitis.

Extracellular processing of proopiomelanocortin generates short beta endorphin that regulates rat keratinocytes via the delta opioid receptor

Discussion

Member takes

Implication

Key Points

Cite This Study

Extracellular processing of proopiomelanocortin generates short beta endorphin that regulates rat keratinocytes via the delta opioid receptor

Discussion

Member takes

Implication

Key Points

Cite This Study

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