What question did this study set out to answer?

This research aims to investigate the localization of POMC-derived peptides and mRNA in the skin of Protopterus annectens.

April 27, 2026Open Access

Proopiomelanocortin (POMC) mRNA and POMC-derived peptides immunolocalization in the skin of Protopterus annectens, an African lungfish

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Randomized trial shows local production of opiate hormones in skin of the African lungfish, suggesting physiological roles.

This research aims to investigate the localization of POMC-derived peptides and mRNA in the skin of Protopterus annectens.
Immunohistochemistry using antisera against ACTH, alpha-MSH, and beta-endorphin
Identification of POMC-like mRNA in epidermal cells using human POMC cDNA as a hybridization probe
Skin samples excised from different regions of the lungfish were analyzed.
Immunoreactivity observed in the epidermis, particularly in the germinal layer
POMC-like mRNA detected in situ in epidermal cells
Positive correlation noted between POMC mRNA and peptide immunoreactivity.

MA et al. (1999) studied this question.

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