What question did this study set out to answer?

The aim is to investigate the expression and localization of POMC-derived peptides in the ovary of Protopterus annectens.

April 27, 2026Open Access

Pro-opiomelanocortin (POMC) expression and immunolocalization of POMC-related peptides in the ovary of Protopterus annectens, an African lungfish

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Randomized trial shows POMC-related peptides are produced in the ovary of Protopterus annectens, indicating local hormone synthesis.

The aim is to investigate the expression and localization of POMC-derived peptides in the ovary of Protopterus annectens.
Used antisera against ACTH, alpha MSH, and beta-endorphin for immunohistochemical localization of POMC-derived peptides
Identified POMC-like mRNA in situ using human POMC cDNA as a hybridization probe in vitellogenic follicles
Examined various follicle stages for immunoreactivity and mRNA labeling
Immunoreactivity for POMC-derived peptides detected in granulosa and internal theca of vitellogenic follicles
No immunoreactivity in immature or primordial follicles
Local production of opiate hormones indicated by the presence of POMC mRNA and related peptides in the same cells

MA et al. (1997) studied this question.

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