Application of the most recent CTD classification criteria revealed a 13% progression rate from UCTD to defined CTDs or RA during a three-year median follow-up. In patients with suspected CTD, evaluation of serological markers beyond ANA may contribute to the diagnosis of UCTD. The establishment of standardized definitions for UCTD is essential to improve the methodological consistency of future studies and to facilitate more accurate prognostic assessments.
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Tuğsal et al. (2025) studied this question.
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