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December 11, 2025Journal of the American Ceramic Society

Polylactic acid/rifampicin/hydroxyapatite/GnPs 3D‐printable composites for targeted antibiotic delivery in bone infections

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Authors

AMAura‐Cătălina MocanuUniversitatea Națională de Știință și Tehnologie Politehnica BucureștiFMFlorin MiculescuUniversitatea Națională de Știință și Tehnologie Politehnica BucureștiEDElena‐Sorina DondeaUniversitatea Națională de Știință și Tehnologie Politehnica București

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Implication

Composite products demonstrate prolonged antimicrobial activity against Staphylococcus aureus in bone infections, indicating potential for new implantable products.

Key Points

  • This research aims to develop novel antibacterial composite materials for targeted antibiotic delivery in bone infections.
  • Created antibacterial composites using polylactic acid, rifampicin, hydroxyapatite, and graphene nanoplatelets through a two-step homogenization process.
  • Assessed the thermal stability of rifampicin at 200°C during processing.
  • Evaluated the antibacterial activity against Staphylococcus aureus and Escherichia coli.
  • Rifampicin showed a positive response for thermal stability and prolonged drug release over 24 hours.
  • Composites maintained strong antibacterial activity against Staphylococcus aureus, relevant to osteomyelitis treatment.
  • Results confirmed the integrity of antimicrobial properties during manufacturing.

Cite This Study

Mocanu et al. (2025) studied this question.

synapsesocial.com/papers/69401b172d562116f28f743fhttps://doi.org/10.1111/jace.70442
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