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December 11, 2025Stem Cell Reviews and ReportsOpen Access

Generation of iPSC-Derived iNKT Cells with Pro-Hematopoietic Activity

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Authors

AKAkhilesh KumarSFSarah FergusonSDSaritha S. D’Souza

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Overview

Generation of iNKT cells from induced pluripotent stem cells enhances cytokine production in bone marrow, indicating potential use post-transplantation.

Key Points

  • The research aims to explore the generation of iNKT cells from induced pluripotent stem cells and their hematopoietic activity.
  • Reprogrammed CD4 + iNKT cells into induced pluripotent stem cells (iNKT-iPSCs)
  • Developed a novel feeder-free 3D spheroid culture method for generating CD34 + cells
  • Re-differentiated CD34 + cells into functional Vα24 + Vβ11 + iNKT cells
  • Generated i-iNKT cells showed pro-hematopoietic activity
  • i-iNKT cells produced cytokines upon CD3 stimulation
  • i-iNKT cells promoted expansion and differentiation of myeloid progenitors

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/69401b1e2d562116f28f77e8https://doi.org/10.1007/s12015-025-11031-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Generation of iPSC-Derived iNKT Cells with Pro-Hematopoietic Activity2025
  2. 2Generation of iNKT cells with hematopoiesis-promoting properties from human iPSCs2025
  3. 3<scp>iPSC</scp> ‐Derived <scp>iNK</scp> Progenitors Engraft and Generate <scp>NK</scp> Cells in Unconditioned and Autologous Immune Humanized Mice2026
  4. 4Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells2026 · 1 citations
  5. 5A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived <scp>natural killer</scp> cells for cancer immunotherapy2024 · 9 citations