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December 10, 2025Frontiers in Pain ResearchOpen Access

From randomized controlled trial to real world clinical evidence: effectiveness and engagement of in-home virtual reality pain treatment for chronic pain in older adults

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Authors

TMTodd MaddoxLos Angeles Valley CollegeJSJosh SackmanLos Angeles Valley CollegeEJEmily JudgePaulsson (United States)

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Overview

Randomized controlled trial demonstrates clinical effectiveness in reducing pain and improving functioning in older adults with chronic lower back pain, suggesting strong engagement with VR therapy.

Key Points

  • To examine the clinical effectiveness and engagement of a virtual reality treatment for chronic lower back pain in older adults.
  • Conducted a secondary analysis of a randomized controlled trial including N = 505 participants.
  • Assessed clinical effectiveness of FDA-Authorized Skills-Based Virtual Reality for pain treatment.
  • Analyzed engagement rates in a separate real-world clinical sample of N = 2460.
  • Both adults and older adults showed equivalent reductions in pain intensity and interference lasting 12 months post-treatment.
  • Patients shifted from high-impact to lower impact chronic pain status at end-of-treatment, maintained at 12 months.
  • Older adults demonstrated higher engagement in VR therapy compared to younger adults.

Cite This Study

Maddox et al. (2025) studied this question.

synapsesocial.com/papers/69401b312d562116f28f7b20https://doi.org/10.3389/fpain.2025.1694007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating Virtual Reality Interventions for Chronic Pain Management in Older Adults2025
  2. 2Sociodemographic Predictors of Clinical Effectiveness, Therapeutic Program Engagement, and Device Usability for an In-Home Virtual Reality Program for Chronic Low Back Pain: Secondary Analysis of a Randomized Controlled Trial2024 · 7 citations
  3. 3Twelve-month results for a randomized sham-controlled effectiveness trial of an in-home skills-based virtual reality program for chronic low back pain2024 · 11 citations
  4. 4In-Home Virtual Reality Program for Chronic Lower Back Pain: A Randomized Sham-Controlled Effectiveness Trial in a Clinically Severe and Diverse Sample2023 · 28 citations
  5. 5Virtual reality for chronic primary low back pain in adults: systematic review protocol2026