Exosomal miR-223-3p from mesenchymal stem cells targets FBXW7 to inhibit intervertebral disc degeneration: mechanism insights

Rui Chen; Ke Cao; Ying Gong; Yin Zhu; Wei Pan; Quan Zhou

doi:10.1186/s13018-025-06468-7

December 10, 2025Journal of Orthopaedic Surgery and ResearchOpen Access

Exosomal miR-223-3p from mesenchymal stem cells targets FBXW7 to inhibit intervertebral disc degeneration: mechanism insights

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Key Points

This research aims to investigate the role of MSC-derived exosomal miR-223-3p in intervertebral disc degeneration.
In vitro experiments using NPCs derived from intervertebral discs
Analysis of miR-223-3p delivery via exosomes
Assessment of apoptosis levels in NPCs
Exosomal miR-223-3p is delivered to NPCs by MSC-derived exosomes
Exosomal miR-223-3p significantly reduces apoptosis in NPCs
Targeting FBXW7 leads to decreased intervertebral disc degeneration progression

Implication

In vitro work shows exosomal mir-223-3p reduces apoptosis in NPCs, suggesting MSC exosomes may combat disc degeneration.

Abstract

MSC-derived exosomes deliver functional miR-223-3p to NPCs. Exosomal miR-223-3p suppresses NPCs apoptosis and attenuates IDD progression by directly targeting and downregulating FBXW7 expression.

Discussion

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/69401b312d562116f28f7ca5 https://doi.org/10.1186/s13018-025-06468-7

View Full Paper

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Exosomal miR-223-3p from mesenchymal stem cells targets FBXW7 to inhibit intervertebral disc degeneration: mechanism insights

Key Points

Implication

Abstract

Discussion

Cite This Study

Exosomal miR-223-3p from mesenchymal stem cells targets FBXW7 to inhibit intervertebral disc degeneration: mechanism insights

Key Points

Implication

Abstract

Discussion

Cite This Study

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