Demonstrates how miR-145-5p and miR-140-5p regulate stem cell differentiation in intervertebral disc degeneration, suggesting new treatments.
The synergistic action of miR-145-5p (via SOX9 targeting) and miR-140-5p promotes BMSC differentiation toward an NPC-like phenotype in vitro, providing mechanistic insight and identifying a potential therapeutic target for disc degeneration that requires future in vivo validation.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: