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December 10, 2025ProteomesOpen Access

Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic Biomarkers

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Authors

LVLorenza VantaggiatoMFMarco FrisendaESEnxhi Shaba

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Overview

Proteomic study identifies stage-specific molecular signatures in non-invasive bladder cancer, suggesting potential prognostic biomarkers.

Key Points

  • This research aims to identify distinct molecular signatures and potential prognostic biomarkers in non-muscle invasive bladder cancer stages.
  • Conducted a top-down proteomic study on fresh biopsies from pTa-LG and pT1-HG NMIBC tumors.
  • Analyzed protein profiles to understand molecular differences at initial diagnosis.
  • Investigated the abundance of specific proteins related to bladder cancer prognosis.
  • Distinct protein profiles were observed between low-grade and high-grade non-invasive bladder cancer.
  • Proteins associated with nitric oxide biosynthesis and signal transduction were highly abundant in high-grade tumors.
  • Multiple proteoforms of PDC6I/ALIX were downregulated in high-grade tumors, indicating their role in apoptosis regulation.
  • Several proteins correlated with tumor size, highlighting their potential as prognostic biomarkers.

Cite This Study

Vantaggiato et al. (2025) studied this question.

synapsesocial.com/papers/69401b3d2d562116f28f8261https://doi.org/10.3390/proteomes13040065
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Also Consider

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  1. 1Response to neoadjuvant chemotherapy according to molecular subtypes in muscle-invasive bladder carcinoma.2024
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  4. 4Molecular genetic subtypes of non-muscle-invasive bladder cancer: their impact on disease prognosis2025
  5. 5Integrating Genetic Alterations and Histopathological Features for Enhanced Risk Stratification in Non-Muscle-Invasive Bladder Cancer2024