What question did this study set out to answer?

The aim is to develop and validate a nomogram for predicting ypN0 in clinically node-positive breast cancer.

December 10, 2025Scientific ReportsOpen Access

Development and validation of a nomogram incorporating YpT stage for predicting ypN0 using multicenter data in clinically node-positive breast cancer

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Authors

HSHideo ShigematsuHiroshima University SSShinsuke SasadaHiroshima University JHJunji HashizumeOnomichi General Hospital

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Implication

Retrospective study shows a nomogram predicts ypN0 in node-positive breast cancer, indicating strong diagnostic performance for surgical de-escalation.

Key Points

The aim is to develop and validate a nomogram for predicting ypN0 in clinically node-positive breast cancer.
Retrospective, multicenter study with 609 patients
Nomogram developed from a training cohort of 330 patients and validated in 279 patients
Evaluated diagnostic performance using AUC, calibration plots, DCA, and PPV
Nomogram showed bias-corrected AUCs of 0.858 and 0.855 in training and validation cohorts, respectively
PPV exceeded 0.90 when predicted probability was ≥ 0.7
Strong discriminative ability supports surgical decision-making for axillary de-escalation

Cite This Study

Shigematsu et al. (2025) studied this question.

synapsesocial.com/papers/69401d542d562116f28f89bf https://doi.org/10.1038/s41598-025-32167-8

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Implication

Retrospective study shows a nomogram predicts ypN0 in node-positive breast cancer, indicating strong diagnostic performance for surgical de-escalation.

Development and validation of a nomogram incorporating YpT stage for predicting ypN0 using multicenter data in clinically node-positive breast cancer

Discussion

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Implication

Key Points

Cite This Study

Development and validation of a nomogram incorporating YpT stage for predicting ypN0 using multicenter data in clinically node-positive breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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