What question did this study set out to answer?

This research aims to evaluate the safety of NADES extract from Glycyrrhiza roots in mice for topical and oral applications.

December 9, 2025MoleculesOpen Access

Safety of NADES Extract of Glycyrrhiza Roots After Topical Application and Peroral Administration to Mice

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This research aims to evaluate the safety of NADES extract from Glycyrrhiza roots in mice for topical and oral applications.
Used NADES extract of Glycyrrhiza roots for topical application and peroral administration.
Conducted LC-MS/MS analysis to identify metabolites in the extract.
Assessed skin irritation through observations and Draize scoring in mice.
Administered varying doses of NADES and extract to evaluate toxicity and LD50.
No skin edema, inflammation, or erythema was observed following topical application at various doses.
The irritation index was calculated as 0.45, indicating mild irritancy under high doses.
Following oral administration, no acute toxic signs or mortality occurred at doses up to 20 g/kg.
LD50 for NADES and extract was determined to be greater than 20 g/kg.

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Implication

This experiment demonstrates low toxicity and safe use of NADES Glycyrrhiza extract in mice, suggesting potential applications in food and pharmaceuticals.

Cite This Study

Shikova et al. (2025) studied this question.

synapsesocial.com/papers/69401d5b2d562116f28f8cb8 https://doi.org/10.3390/molecules30244704

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Implication

This experiment demonstrates low toxicity and safe use of NADES Glycyrrhiza extract in mice, suggesting potential applications in food and pharmaceuticals.

Safety of NADES Extract of Glycyrrhiza Roots After Topical Application and Peroral Administration to Mice

Key Points

Discussion

Implication

Cite This Study

Safety of NADES Extract of Glycyrrhiza Roots After Topical Application and Peroral Administration to Mice

Key Points

Discussion

Implication

Cite This Study

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