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December 9, 2025Frontiers in OncologyOpen Access

Efficacy and toxicity of neoadjuvant radiotherapy with concomitant dose escalation for rectal cancer

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Authors

PWPeng WangKLKai LiuXLXiaoliang Liu

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Overview

Study evaluates neoadjuvant radiotherapy's impact on primary tumor response in rectal cancer, indicating effective treatment outcomes.

Key Points

  • The study aimed to evaluate the efficacy of neoadjuvant radiotherapy with dose escalation in treating rectal cancer patients.
  • Reviewed clinical records of rectal cancer patients treated with neoadjuvant chemoradiotherapy and dose escalation.
  • Included a regimen of 55-56 Gy of radiotherapy followed by surgery 8-10 weeks later.
  • Analyzed outcomes including pathological complete response rates and sphincter preservation.
  • Achieved a pCR rate of 23.9% with 99 out of 415 patients showing a complete response.
  • Sphincter preservation was achieved in 86.5% of patients.
  • Patients with pCR had significantly better disease-free survival at 83.33%.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69401d5b2d562116f28f8ce4https://doi.org/10.3389/fonc.2025.1725405
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of Pathological Complete Response with Long-Term Oncological Outcomes After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Retrospective Analysis of 327 Patients2026
  2. 2Neoadjuvant Therapy in Locally Advanced Rectal Cancer—What Result Should We Expect?2026
  3. 3Impact of Dose-Escalated Chemoradiation on Pathological Complete Response in Patients with Locally Advanced Rectal Cancer2024
  4. 4AB068. SOH24AB_083. Retrospective analysis of pathological complete response following neo-adjuvant chemoradiotherapy or neo-adjuvant radiotherapy in locally advanced rectal cancer at a single Irish centre2024
  5. 5Impact of Dose-Escalated Chemoradiation on Pathological Complete Response in Patients with Locally Advanced Rectal Cancer2024