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December 9, 2025Nature Computational Science12 citationsOpen Access

SciSciGPT: advancing human–AI collaboration in the science of science

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ESErzhuo ShaoYWYifang WangYQYifan Qian

Key Points

  • To present SciSciGPT as a prototype AI collaborator and evaluate its effectiveness in research workflows.
  • Introduced an open-source AI prototype named SciSciGPT for the science of science domain.
  • Explored its capabilities through case studies covering various research tasks.
  • Proposed a capability maturity model for human-AI collaboration to guide future development.
  • Demonstrated enhanced reproducibility and efficiency in empirical research tasks using SciSciGPT.
  • Highlighted the potential of AI to facilitate transparency in scientific inquiry.
  • Identified critical challenges such as ethical use and balancing contributions of human and AI.

Abstract

We introduce SciSciGPT, an open-source, prototype artificial intelligence (AI) collaborator that uses the domain of science of science as a testbed to explore the potential of large language model-powered research tools. SciSciGPT automates complex workflows, supports diverse analytical approaches, accelerates research prototyping and iteration and facilitates reproducibility. Through case studies, we demonstrate its ability to streamline a wide range of empirical and analytical research tasks while highlighting its broader potential to advance research. We further propose a large language model agent capability maturity model for human-AI collaboration, envisioning a roadmap to further improve and expand upon frameworks such as SciSciGPT. As AI capabilities continue to evolve, frameworks such as SciSciGPT may play increasingly pivotal roles in scientific research and discovery. At the same time, these new advances also raise critical challenges, from ensuring transparency and ethical use to balancing human and AI contributions. Addressing these issues may shape the future of scientific inquiry and inform how we train the next generation of scientists to thrive in an increasingly AI-integrated research ecosystem.

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Cite This Study

Shao et al. (2025) studied this question.

synapsesocial.com/papers/69401d622d562116f28f8e23https://doi.org/10.1038/s43588-025-00906-6
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