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September 7, 2026ACM Computing SurveysOpen Access

Transforming Science with Large Language Models: A Survey on AI-assisted Scientific Discovery, Experimentation, Content Generation, and Evaluation

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Authors

SESteffen EgerCYCao YongJDJennifer D’Souza

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Overview

Literature survey demonstrates the transformative impact of large language models across scientific research, highlighting emerging discovery tools and critical risks to research integrity.

Key Points

  • To provide a comprehensive overview of core techniques, datasets, and evaluation methodologies for deploying large multimodal language models across the scientific lifecycle.
  • Curated literature across five scientific phases: literature search, hypothesis generation and experimentation, text production, multimodal artifact generation, and peer review.
  • Assessed evaluation benchmarks, methodological trends, systemic limitations, and ethical risks across generative scientific tools.
  • Cataloged rapid progress in multimodal language models capable of formulating novel research questions, drafting manuscripts, and synthesizing figures.
  • Identified significant challenges regarding hallucinated outputs, reproducibility limitations, and emerging risks to peer-review integrity.

Cite This Study

Eger et al. (2026) studied this question.

synapsesocial.com/papers/6a9e8531c3034f961570d552https://doi.org/10.1145/3845596
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Also Consider

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  1. 1The empowerment of Science of Science by large language models: New tools and methods2026
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  5. 5Balancing Practical Uses and Ethical Concerns:The Role of Large Language Models in Scientific Research2025 · 2 citations