Age modifies the association between sex and the plasma inflammatory proteome in treated HIV

Rebecca Abelman; Samuel R Schnittman; Natália Faraj Murad; Adam B. Olshen; Gabriele Beck‐Engeser; Nayara S. S. Aquino; Gabrielle C. Ambayec; Edward R. Cachay; Joseph J. Eron; Michael S Saag; Robin M. Nance; Joseph A. Delaney; Stephanie A. Ruderman; Richard D. Moore; Kenneth H. Mayer; Jeffrey M. Jacobson; Heidi M. Crane; Peter W. Hunt

doi:10.1172/jci196869

Key Points

To examine how age affects the relationship between sex and inflammation in people with HIV.
Analyzed systemic Type I interferon responses and inflammatory proteome in treated HIV patients.
Focused on differences between older men and women with HIV.
Older women living with HIV exhibit greater inflammation compared to older men.
Most proteins linked with mortality risk are more present in older women.

Abstract

The menopausal transition appears to have a dramatic eﬀect on systemic Type I interferon responses and the broader inﬂammatory proteome in women with HIV. Among older PWH, women have greater inﬂammation than men, including the majority of proteins linked with mortality risk.

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Abelman et al. (2025) studied this question.

synapsesocial.com/papers/69401d732d562116f28f94c7 https://doi.org/10.1172/jci196869

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Age modifies the association between sex and the plasma inflammatory proteome in treated HIV

Key Points

Abstract

Discussion

Cite This Study

Age modifies the association between sex and the plasma inflammatory proteome in treated HIV

Key Points

Abstract

Discussion

Cite This Study

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