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December 8, 2025ACS Infectious Diseases

Structure, Function, and Inhibition of Adenylosuccinate Lyase (ADSL) from Mycobacterium tuberculosis

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Authors

VSVigyasa SinghKCKe ChenSSSubodh Kumar Samrat

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Overview

Kinetic analysis and high-throughput screening identify inhibitors of adenylosuccinate lyase in Mycobacterium tuberculosis, suggesting potential for new antitubercular agents.

Key Points

  • Inhibitors were identified through high-throughput screening targeting adenylosuccinate lyase activity.
  • Kinetic analysis revealed effective inhibition of adenylosuccinate lyase in Mycobacterium tuberculosis.
  • The approach utilized a bioluminescent assay and confirmed specificity against human adenylosuccinate lyase.
  • These findings highlight adenylosuccinate lyase as a viable target for developing new treatments for tuberculosis.

Cite This Study

Singh et al. (2025) studied this question.

synapsesocial.com/papers/69401f062d562116f28fa0a9https://doi.org/10.1021/acsinfecdis.5c00442
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