Analysis shows improved drug solubility and reduced off-target effects with cyclodextrin carriers, suggesting better clinical outcomes.
Although cyclodextrin-based systems have demonstrated promising improvements in drug solubility, stability, and target specificity, challenges remain with regard to overcoming biological barriers and minimizing off-target effects. The authors believe that continued optimization of carrier design, combined with advances in targeting and stimuli-responsive technologies, will be crucial for translating these innovative systems into effective clinical therapies.
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Hussein et al. (2025) studied this question.
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