Analysis reveals environmental strains of Morganella intermedius may acquire antimicrobial resistance genes, suggesting urgent clinical surveillance needs.
We conducted the first molecular epidemiological analysis of Morganella intermedius, a novel genospecies of Morganella morganii frequently isolated from environmental sources. We identified specific advantages unique to M. intermedius , including the presence of more flagellar-related genes, which may enhance its environmental adaptability. Additionally, we explained the reduced number of antimicrobial resistance genes in M. intermedius , which could be attributed to its possession of more type II and type III restriction–modification systems compared to M. morganii and Morganella sibonii . Most importantly, we propose that environmental M. intermedius strains may contribute to clinical infections, and clinical strains showed the potential to acquire important antimicrobial resistance genes. This underscores the urgent need for increased clinical awareness and enhanced surveillance of this emerging genospecies.
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Chen et al. (2025) studied this question.
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