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December 8, 2025The Indian Journal of Medical ResearchOpen Access

Body composition following gender affirming hormone therapy in transgender individuals

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Authors

BKBharathi KollaPKPramila Kalra

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Overview

Observational analysis reveals hormonal therapy affects muscle mass and body composition in transgender individuals, highlighting differing outcomes across genders.

Key Points

  • Body composition changes significantly following hormonal therapy in transgender individuals, with notable increases in fat and decreases in muscle mass.
  • After 12 months, transwomen saw subcutaneous fat increase by 9.2% and visceral fat by 11.3%, while muscle strength decreased significantly.
  • Bioelectrical impedance analysis was used to assess changes in muscle mass and body composition in both transfemales and transmales.
  • Irisin levels remained unchanged post-treatment, suggesting limited correlation with changes in muscle mass or fat mass.

Cite This Study

Kolla et al. (2025) studied this question.

synapsesocial.com/papers/69401f142d562116f28fa5fehttps://doi.org/10.25259/ijmr_560_2025
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Also Consider

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  1. 1Bone Mass in Young Adulthood Following Gonadotropin-Releasing Hormone Analog Treatment and Cross-Sex Hormone Treatment in Adolescents With Gender Dysphoria2014 · 249 citations
  2. 2Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise2021 · 65 citations
  3. 3Change in Visceral Fat and Total Body Fat and the Effect on Cardiometabolic Risk Factors During Transgender Hormone Therapy2021 · 67 citations
  4. 4Bone Mass Effects of Cross-Sex Hormone Therapy in Transgender People: Updated Systematic Review and Meta-Analysis2019 · 63 citations
  5. 5Change in grip strength in trans people and its association with lean body mass and bone density2019 · 64 citations