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December 8, 2025TransfusionOpen Access

Heart rate changes in chronically red cell transfusion‐dependent patients—A dose‐dependent effect of red cell transfusion: A randomized cross‐over trial, interim analysis

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Authors

RTRik Paulus Bernardus ToninoRBRolf E. BrouwerJZJaap Jan Zwaginga

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Overview

Randomized cross-over trial assesses heart rate and quality of life changes in patients with myeloproliferative neoplasms, highlighting effects of hemoglobin levels.

Key Points

  • Heart rate decreases as hemoglobin levels increase in transfusion-dependent patients, suggesting improved oxygen delivery.
  • The trial showed notable heart rate reductions, particularly with the highest transfusion regimen of two additional units.
  • Conducted as a randomized cross-over trial, the interim analysis involved 12 patients on three different transfusion regimens.
  • Further investigation may be warranted for potential quality of life and cognitive performance improvements noted.

Cite This Study

Tonino et al. (2025) studied this question.

synapsesocial.com/papers/694020d72d562116f28fa739https://doi.org/10.1111/trf.70023
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