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December 8, 2025European Journal of Clinical Investigation

Real‐world evidence and observational studies: Methodological challenges in clinical research

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Authors

CZCarmine ZoccaliGTGiovanni Tripepi

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Overview

Observational studies reveal patient outcomes in clinical research, highlighting challenges in data quality and analysis.

Key Points

  • Methodological challenges complicate real-world evidence studies, particularly in clinical research and patient outcomes.
  • Advanced statistical techniques like propensity score matching can help address confounding in observational studies.
  • Data quality issues such as missing data and misclassification further complicate analysis, necessitating rigorous methods.
  • Transparent reporting and adherence to guidelines are crucial for enhancing the credibility of clinical research findings.

Cite This Study

Zoccali et al. (2025) studied this question.

synapsesocial.com/papers/694020e22d562116f28fabbehttps://doi.org/10.1111/eci.70153
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  5. 5Real-World Evidence: Better than Nothing or the Future? A Perspective on Clinical Evidence Generation in Interventional Oncology2025 · 6 citations