Review reveals the role of vaccine design and host factors in durable immune responses from mRNA and protein platforms, indicating future developments in vaccine strategies.
Durable vaccine-induced immunity is the basis of long-term protection against infection and disease. This review covers three topics. First, we describe the immunological foundations of durable response and its determinants (e.g., vaccine design, host, and pathogen factors). Second, we summarize the current evidence regarding the durable immune responses conferred by mRNA- and adjuvanted protein-based vaccine platforms. Lastly, we discuss the challenges in developing durable mRNA vaccines and outline future considerations.
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Pena et al. (2025) studied this question.
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