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December 7, 2025Drug DeliveryOpen Access

Modeling the synergistic enhancement of drug permeation by a dual-microbubble system under ultrasonic excitation

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Authors

YLYingjie LiJHJiwen HuYWYunsu WangFujian University of Traditional Chinese Medicine

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Overview

Modeling improved drug delivery through a dual-microbubble system in relation to vascular endothelial permeability.

Key Points

  • Drug delivery is enhanced through a dual-microbubble system, highlighting significant improvements in endothelial permeability.
  • The finite element method is utilized to model interactions and optimize parameters such as microbubble size and spacing.
  • Research findings indicate strong dependencies of drug permeability on acoustic parameters and blood viscosity.
  • This method supports precise modulation of vascular endothelial permeability for therapeutic applications.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/694020ee2d562116f28fb099https://doi.org/10.1080/10717544.2025.2597621
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  5. 5Cross-scale mechanistic insights into pulse-length dependent BBB opening.2026