December 7, 2025JCI InsightOpen Access

Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism

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Authors

SDSaeed DaneshmandiRoswell Park Comprehensive Cancer Center EKEun‐A KoJeju National University YQYan QiShihezi University

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Implication

Observational analysis shows glucose metabolism manipulation lowers graft-versus-host disease severity, suggesting 6PGD could be a viable therapeutic target.

Key Points

Reducing graft-versus-host disease severity enhances outcomes in T cell therapy with glucose metabolism modulation.
Targeting 6-phosphogluconate dehydrogenase improved aGvHD outcomes in murine models, significantly lowering mortality rates.
Inhibition of the pentose phosphate pathway through pharmacological blockade altered T cell metabolism favorably.
Preserving graft-versus-tumor effects while reducing aGvHD highlights a promising therapeutic strategy for effective T cell responses.

Cite This Study

Daneshmandi et al. (2025) studied this question.

synapsesocial.com/papers/694020f72d562116f28fb280 https://doi.org/10.1172/jci.insight.192774

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Implication

Observational analysis shows glucose metabolism manipulation lowers graft-versus-host disease severity, suggesting 6PGD could be a viable therapeutic target.

Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism

Discussion

Member takes

Implication

Key Points

Cite This Study

Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism

Discussion

Member takes

Implication

Key Points

Cite This Study

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