Beyond the matrix: rethinking antibiotic tolerance in CF biofilms using 3D models

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Increased tolerance observed in Pseudomonas aeruginosa biofilms, particularly to colistin and ciprofloxacin, highlights a significant challenge.
Antibiotic efficacy was tested with 3D biofilm models created using acetylated alginate and DNA to mimic mucoid biofilms.
Model findings suggest that the biofilm matrix contributes to bacterial tolerance rather than solely diffusive limitations.
Challenges traditional notions of antibiotic diffusion, indicating a need to rethink strategies for managing chronic lung infections.

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This analysis demonstrates increased antibiotic tolerance in Pseudomonas aeruginosa biofilms, suggesting new approaches for antibiofilm therapies.

Olivier Guillaume (2025) studied this question.

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This analysis demonstrates increased antibiotic tolerance in Pseudomonas aeruginosa biofilms, suggesting new approaches for antibiofilm therapies.