This editorial emphasizes the role of epigenetics in improving migraine efficacy and safety through neuropharmacology and personalized medicine.
The role of epigenetic modifications of genes involved in the CGRP pathway, synaptic plasticity and TRPV1, TRPA1 and estrogen receptor signaling in migraine is emerging. Therefore, a deeper understanding of the impact of epigenetics in migraine pathophysiology and neuropharmacology is needed to revert chronification and personalize medicine in the field of migraine, improving efficacy and safety of treatments and widening the therapeutic armamentarium.
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Scuteri et al. (2025) studied this question.
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