What does this research mean for the field?

Genetic variations significantly influence migraine susceptibility and therapeutic response, underscoring the need to integrate genetic insights into clinical practice to optimize personalized treatment strategies. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review investigates the relationship between genetic factors and the efficacy of migraine treatments, focusing on personalized approaches.

May 17, 2026Current Drug Research Reviews

Genetic Framework of Migraine: An Insight into the Genetic Alterationsand Novel Pharmacotherapeutic Approaches of Migraine Disorder

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Authors

PKPritam KamilaCDA College KKKoyel KarCDA College SCSailee ChowdhuryCDA College

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Implication

Review examines genetic influences on migraine treatment efficacy and explores new therapies.

Key Points

This review investigates the relationship between genetic factors and the efficacy of migraine treatments, focusing on personalized approaches.
Literature review on migraine pathophysiology and genetic contributions, especially familial hemiplegic migraine.
Assessment of pharmacological interventions including triptans, NSAIDs, anticonvulsants, antidepressants, calcium channel blockers, and emerging therapies.
Evaluation of genetic variations on drug efficacy, metabolism, and safety.
Genetic mutations influence migraine susceptibility and treatment response.
Triptans and NSAIDs are first-line acute treatments; anticonvulsants and antidepressants are effective for prophylaxis.
Emerging therapies such as CGRP-targeted agents and gepants offer alternatives for patients not responding to traditional treatments.

Cite This Study

Kamila et al. (2026) studied this question.

synapsesocial.com/papers/6a095c037880e6d24efe1f06 https://doi.org/10.2174/0125899775397796251127080823

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Genetic Framework of Migraine: An Insight into the Genetic Alterationsand Novel Pharmacotherapeutic Approaches of Migraine Disorder

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Key Points

Cite This Study

Genetic Framework of Migraine: An Insight into the Genetic Alterationsand Novel Pharmacotherapeutic Approaches of Migraine Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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