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March 14, 2026CNS & Neurological Disorders - Drug Targets

Pharmacology and Pharmacogenomics of Anti-Migraine Drugs

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Authors

AMAnanya MisraASArya SolankiCentral University of PunjabPSPrachi SahuCentral University of Punjab

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Implication

This review highlights pharmacogenomic insights impacting migraine treatment, suggesting new personalized strategies.

Key Points

  • The aim is to explore how genetic variations affect the efficacy and safety of anti-migraine drugs.
  • Review of relevant pharmacogenomic research findings
  • Analysis of genetic variants linked to migraine therapy outcomes
  • Evaluation of pharmacokinetic and pharmacodynamic pathways
  • Genetic variants influence treatment responses and medication effectiveness in migraines.
  • Certain gene polymorphisms affect calcium channel blockers and triptans' efficacy.
  • CGRP receptor antagonists' effectiveness varies among individuals based on genetic markers.

Cite This Study

Misra et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc44b39f7826a300d0e1https://doi.org/10.2174/0118715273402957251210064344
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Framework of Migraine: An Insight into the Genetic Alterations and Novel Pharmacotherapeutic Approaches of Migraine Disorder2026
  2. 2Genetics of migraine: a systematic review and meta-analysis of 21 genes2026 · 1 citations
  3. 3Translational Impact of Genetics and Epigenetics of CGRP System on Chronic Migraine Treatment with Onabotulinumtoxin A and Other Biotech Drugs2025 · 5 citations
  4. 4Integrating Pharmacodynamic Data to Prioritise Candidate Migraine Genes and Pathways Using a Novel Bioinformatics Workflow2026
  5. 5Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches2025