What question did this study set out to answer?

This review aims to analyze genetic variants linked to migraine susceptibility through a systematic meta-analysis.

Genetics of migraine: a systematic review and meta-analysis of 21 genes

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Systematic review identifies genetic risk factors associated with migraines, suggesting new management strategies.

This review aims to analyze genetic variants linked to migraine susceptibility through a systematic meta-analysis.
Conducted a systematic review following PRISMA guidelines
Performed pooled analysis using electronic database literature
Utilized the NOS tool for quality assessment and association analysis
Applied odds ratios and confidence intervals to evaluate genetic associations
Assessed publication bias and heterogeneity with specific statistical tests
Identified significant associations between migraine and various genetic variants
Highlighted BDNF as a central node in protein–protein interaction networks
Classified genetic variants into functional groups related to estrogen signaling and neuropeptide regulation
Supported the concept of a genetic basis for migraine across different populations

Sudershan et al. (2026) studied this question.

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