Key result
Diuretics and agents acting on the renin-angiotensin system were associated with an increased risk of migraine, with 37 target genes identified for migraine and 22 for migraine with aura.
Why the study?
Contraindicated medications and their corresponding target genes for migraine and its subtypes needed to be identified.
Are diuretics and agents that act on the renin-angiotensin system associated with an increased risk of migraine based on genetic evidence?
Population
GWAS summary data for 14 medication-use categories from UK Biobank and migraine from FinnGen
Comparison
14 medication-use categories evaluated for associations with migraine and its subtypes
Design
Mendelian randomization and transcriptome-wide association study
Authors
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Associations should not yet alter prescribing; leaves open causal migraine links and pharmacogenetic targets.
Observational
Yes
Are diuretics and agents that act on the renin-angiotensin system associated with an increased risk of migraine based on genetic evidence?
Genetic analyses suggest that diuretics and renin-angiotensin system agents may increase the risk of migraine, identifying specific target genes that could inform preventive strategies.
Nan et al. (2025) conducted an observational in Migraine and its subtypes. Diuretics and agents that act on the renin-angiotensin system was evaluated on Risk of migraine and migraine with aura. Diuretics and agents acting on the renin-angiotensin system were associated with an increased risk of migraine, with 37 target genes identified for migraine and 22 for migraine with aura.
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