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December 5, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Cytokine dynamics in the blood and cerebrospinal fluid of HIV/AIDS patients with cryptococcal meningitis receiving antifungal therapy

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Authors

RSRui SuWuhan Polytechnic UniversitySZShuwei ZhaoKunming Medical UniversityYLYu‐Ye LiKunming Medical University

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Overview

Analysis reveals cytokine changes in plasma and cerebrospinal fluid of cryptococcal meningitis patients, indicating immune cell response to antifungal therapy.

Key Points

  • Cytokines in cerebrospinal fluid show significant changes during antifungal therapy in cryptococcal meningitis patients.
  • After treatment, specific cytokines like IL-2 and IL-10 decrease in conjunction with immune cell adaptations.
  • Immune analysis assessed cytokine levels and cell counts, identifying correlations with neutrophils and leukocytes.
  • Results highlight immune dynamics that may inform future treatment options for HIV-associated infections.

Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/694022442d562116f28fbb67https://doi.org/10.3389/fcimb.2025.1691025
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